TRANSLATIONAL PHYSIOLOGY Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease
نویسندگان
چکیده
Tatiana V. Tkatchenko,* Ricardo A. Moreno-Rodriguez,* Simon J. Conway, Jeffery D. Molkentin, Roger R. Markwald, and Andrei V. Tkatchenko Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan; Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana; and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
منابع مشابه
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
The Postn gene encodes protein periostin. During embryonic development, it is highly expressed in the outflow tract (OFT) endocardial cushions of the developing heart, which give rise to several structures of the mature heart including the aortic valve. Periostin was previously implicated in osteoblast differentiation, cancer metastasis, and tooth and bone development, but its role in cardiac O...
متن کاملDiet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
OBJECTIVE Calcific aortic valve disease is similar to atherosclerosis in that both diseases result from chronic inflammation and endothelial dysfunction. Heterozygous NOTCH1 mutations have been associated to calcific aortic disease and a bicuspid aortic valve. We investigated whether mice with genetic inactivation of the Notch signaling pathway are prone to develop valve disease when exposed to...
متن کاملInhibitory Role of Notch1 in Calcific Aortic Valve Disease
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling pathway is critical for multiple cell differentiation processes, but its role in the development ...
متن کاملCell Biology/Signaling Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL
Objective—Calcific aortic valve disease is similar to atherosclerosis in that both diseases result from chronic inflammation and endothelial dysfunction. Heterozygous NOTCH1 mutations have been associated to calcific aortic disease and a bicuspid aortic valve. We investigated whether mice with genetic inactivation of the Notch signaling pathway are prone to develop valve disease when exposed to...
متن کاملNotch1 represses osteogenic pathways in aortic valve cells.
Calcific aortic stenosis is the third leading cause of adult heart disease and the most common form of acquired valvular disease in developed countries. However, the molecular pathways leading to calcification are poorly understood. We reported two families in which heterozygous mutations in NOTCH1 caused bicuspid aortic valve and severe aortic valve calcification. NOTCH1 is part of a highly co...
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